Stayed here several times:
biker friendly, motorcycle friendly,
www.bikersbedsfrance.co.uk
Two hours or so down the A26 to clear the clutter and boring roads etc, then a nice cross country run to the B&B, handy for heading to Black Forest / Vosges.
Or head a bit more Eastwards in the Ardennes area, lots of nice places to stay in Belgium, you could reach Bastogne in about 4 hours (hotel Melba) or my preference these days would probably be Bouillon and Hotel de la Poste.
Hotel de la Poste biedt u een verscheidenheid aan authentieke kamers met een vier sterren-standaard. Trakteer uzelf op een onvergetelijke ervaring in een historisch gebouw, wiens charme bewaard is gebleven sinds 1730.
www.hotelposte.be
Really depends on where you are heading - Germany / Switzerland covers a good few hundred miles north-to-south. Personally I tend to blast at least 2 hours of Motorway to make some progress, often 3-4 hours, doing this out and back gets you an extra day in the nice areas and your not missing much by not riding along slower roads with few nice curves that go through one town and village after another.
Troyes is a stunning little city and well worth a stop, and on the way towards Switzerland, but is pretty much 4 hours of Motorway from Calais (maybe 3 if you do a ton all the way) we have sayed here a few times, website is shit, but Hotel is good, secure parking and right in the old part of town - google images for Troyes if you are not familiar with it.
Découvrez le Brit Hotel Comtes de Champagne situé dans le centre-ville ! Profitez de son confort et de l'ensemble de ses services.
hotel-troyes.brithotel.fr
Best to work out where you want to be on the second night and plot a rought route, then you will know where you need to stop on the 1st night, but the reality is you can choose from hundreds of Hotels and most of them will be good, never eneded up in a real dump in the 20 or so Euro trips I have done.